The John Lewis at Home store at Mannington Retail Park is to close.
A statement issued by the company earlier today confirmed a decision which had long been rumoured.
The Swindon branch is to close along with other At Home stores in Newbury, Tamworth and Croydon.
The firm's statement said that if redundancies were confirmed, efforts would be made to ensure staff - known as Partners - who wanted to remain would be found new roles.
Company chair Sharon White said: "Closing a shop is always incredibly difficult and today’s announcement will come as very sad news to customers and Partners.
"However, we believe closures are necessary to help us secure the sustainability of the Partnership - and continue to meet the needs of our customers however and wherever they want to shop.
"Redundancies are always an absolute last resort and we will do everything we can to keep as many Partners as possible within our business.
“There are many reasons to be optimistic about the Partnership’s future. Waitrose and John Lewis are two of the UK’s most loved and trusted brands and we have adapted to the challenges of the pandemic by responding to the new needs of customers."